Abstract
Recent genome editing techniques have substantially simplified the generation of genetically modified mice. A new study combines adeno-associated viruses (AAV) and electroporation to generate a robust pipeline to deliver CRISPR-Cas reagents into mouse embryos.
Recent genome editing techniques have substantially simplified the generation of genetically modified mice. A new study combines adeno-associated viruses (AAV) and electroporation to generate a robust pipeline to deliver CRISPR-Cas reagents into mouse embryos.
Institute Authors
Group leader
Labs & Facilities
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All publications
https://royalsocietypublishing.org/rsob/article/16/8/260089/482862/CDK1-Cyclin-B-mediated-phosphorylation-of-PP2A-B56
CDK1-Cyclin B mediated phosphorylation of PP2A-B56 on B56Par1.T73T75 controls mitotic entry timing and Schizosaccharomyces pombe cell size
19 August 2026
Institute Authors (3)
Lenka Halova, Duncan Smith, Iain Hagan
Labs & Facilities
Biological Mass Spectrometry
Research Group
Cell Division
19 August 2026
https://www.cell.com/immunity/fulltext/S1074-7613(26)00278-5
CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity
4 August 2026
Institute Authors (10)
Erin Richardson, Shih-Chieh Chiang, Massimo Russo, Charles Earnshaw, Anna Pidoux, Poppy Dunn, Sudhakar Sahoo, Antonia Banyard, Natalia Moncaut, Santiago Zelenay
Labs & Facilities
BRU Experimental Team, Computational Biology Support, Genome Editing and Mouse Models, Mass and Flow Cytometry, Transgenic Breeding Team
Research Group
Cancer Inflammation and Immunity
4 August 2026
https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2
Plasma signals of lung tumor promotion for molecular cancer prevention
25 June 2026
Institute Authors (1)
William Hill
Research Group
Cancer Origins
25 June 2026
https://link.springer.com/article/10.1038/s44319-026-00809-1
PKMYT1 has an important role in the timing and fidelity of chromosome segregation
5 June 2026
Institute Authors (6)
Asma Belbelazi, Charlie Greenaway-Wells, Zoe Edwards, Wendy Trotter, Keren Dawson, Iain Hagan
Research Group
Cell Division
5 June 2026
https://www.nature.com/articles/s42255-026-01514-y
Tissue-specific fibroblast lipid cues impose the rate of epithelial cancer invasion
27 April 2026
Institute Authors (4)
Amaya Virós, Noah Palombo, Charlotte Russell, Claus Jørgensen
Research Group
Skin Cancer & Ageing
27 April 2026
https://www.cell.com/cancer-cell/fulltext/S1535-6108(26)00114-5
Immunometabolic gatekeeping: How tissue metabolism conditions tumor immunity
13 April 2026
Institute Authors (1)
Samra Turajlić
Research Group
Cancer Dynamics
13 April 2026
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Amaya Virós
CRUK Advanced Clinician Scientist Fellow
“We are so pleased to have received the funding to enable us to test our hypothesis in the lab. If we can create a new medicine that can precisely target a specific type of cell within the tumour, and restore anti-cancer immune responses, this will be a game-changer for oesophageal cancer patients “
Sara Valpione
Former Institute Clinical Fellow and now Clinician in Residence within the CRUK National Biomarker Centre
“My charity bake sales – known as “David’s Great British Bake Off” – are always a hit, home baked products taste so much better than shop bought and are greatly appreciated by staff!”
David Jenkins
Purchasing Officer
“We’ve seen some remarkable responses, with an improvement for some patients within days. This is an early phase trial so there’s a lot more work to do. But the data we have so far is very encouraging and could help many thousands of people in the future”
Tim Somervaille
Senior Group Leader
“It is a pleasure to introduce my team who work to deliver our research goals. We work in a friendly and collaborative environment, supporting each other’s projects. “
Amaya Virós
CRUK Advanced Clinician Scientist Fellow